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PET shows link between endorphins, depression
Researchers have found more evidence that depression has its roots in specific alterations within the brain, particularly in the endorphin system that is a central part of the brain's natural pain and stress reduction capability.
Researchers have found more evidence that depression has its roots in specific alterations within the brain, particularly in the endorphin system that is a central part of the brain's natural pain and stress reduction capability.
Susan Kennedy, Ph.D., and colleagues at the University of Michigan Molecular and Behavioral Neuroscience Institute evaluated 28 women, 14 with major depression, and 14 healthy controls. Subjects were asked to recall a sad life event while undergoing PET with radiolabeled carfentanil. Nondepressed women did not activate their micro-opioid system. Depressed women's micro-opioid system, however, was overactive even at baseline (Arch Gen Psych 2006:63;1199-1206).
This is the first time that specific differences in the micro-opioid system have been shown between people with depression and those without, according to the study.
Study Reaffirms Low Risk for csPCa with Biopsy Omission After Negative Prostate MRI
December 19th 2024In a new study involving nearly 600 biopsy-naïve men, researchers found that only 4 percent of those with negative prostate MRI had clinically significant prostate cancer after three years of active monitoring.
Study Examines Impact of Deep Learning on Fast MRI Protocols for Knee Pain
December 17th 2024Ten-minute and five-minute knee MRI exams with compressed sequences facilitated by deep learning offered nearly equivalent sensitivity and specificity as an 18-minute conventional MRI knee exam, according to research presented recently at the RSNA conference.
Can Radiomics Bolster Low-Dose CT Prognostic Assessment for High-Risk Lung Adenocarcinoma?
December 16th 2024A CT-based radiomic model offered over 10 percent higher specificity and positive predictive value for high-risk lung adenocarcinoma in comparison to a radiographic model, according to external validation testing in a recent study.
