Coronary imaging trial zeroes in on plaque risk
A large prospective trial found plaque burden and plaques involving small lumen area are as likely as classically defined vulnerable plaques to trigger a myocardial infarction.
A large prospective trial found plaque burden and plaques involving small lumen area are as likely as classically defined vulnerable plaques to trigger a myocardial infarction.
The Providing Regional Observations to Study Predictors of Events in the Coronary Tree (PROSPECT) trial is the first study of atherosclerosis using multimodality imaging. Principal investigator Dr. Gregg W. Stone and colleagues at New York-Presbyterian Hospital/Columbia University Medical Center studied 700 patients with acute coronary syndromes using angiography, intravascular ultrasound, and virtual histology analysis of IVUS-acquired radiofrequency data.
Most untreated plaques that cause unexpected heart attacks are not mild lesions, as previously thought, but actually have a large plaque burden and a small lumen area, the researchers found. These characteristics were invisible on the coronary angiogram but easily identifiable on IVUS. Findings were released at the 2009 Transcatheter Cardiovascular Therapeutics scientific symposium in San Francisco.
Can Ultrasound-Based Radiomics Enhance Differentiation of HER2 Breast Cancer?
March 11th 2025Multicenter research revealed that a combined model of clinical factors and ultrasound-based radiomics exhibited greater than a 23 percent higher per patient-level accuracy rate for identifying HER2 breast cancer than a clinical model.
