Contrast-Enhanced Digital Mammography as Supplemental Exam
Supplemental imaging with CEDM may help detect cancer among women at high risk for cancer.
Contrast-enhanced digital mammography (CEDM) could be valuable as a supplemental imaging exam for women at increased risk for breast cancer who do not meet the criteria for MRI or for whom access to MRI is limited, according to a study published in the European Journal of Radiology.
Researchers from Memorial Sloan Kettering Cancer Center in New York, NY, undertook a pilot study to prospectively compare screening CEDM to breast MRI in women with an increased risk for breast cancer
A total of 318 women participated in the study; 307 were evaluable. All underwent CEDM within 30 days of a scheduled screening MRI; CEDM was interpreted blinded to MRI. The reference standard was defined as a combination of pathology and 2-year imaging follow-up.
The results revealed two invasive cancers and one ductal carcinoma in situ at the first round of screening: MRI detected all three cancers and CEDM detected the two invasive cancers. None of the three cancers was seen on the low energy mammograms, comparable to conventional mammography.
The researchers found five additional screen-detected cancers at 2-year imaging follow-up, but no palpable cancers. The positive predictive value 3 (PPV3) for CEDM was 15% and 14% for MRI. The specificity of CEDM and MRI were 94.7% and 94.1% respectively.
The researchers concluded that CEDM could be valuable as a supplemental imaging exam for women at increased risk for breast cancer who do not meet the criteria for MRI or for whom access to MRI is limited. Further study is required, however.
AI-Initiated Recalls After Screening Mammography Demonstrate Higher PPV for Breast Cancer
March 18th 2025While recalls initiated by one of two reviewing radiologists after screening mammography were nearly 10 percent higher than recalls initiated by an AI software, the AI-initiated recalls had an 85 percent higher positive predictive value for breast cancer, according to a new study.
ECR Mammography Study: Pre-Op CEM Detects 34 Percent More Multifocal Masses than Mammography
February 28th 2025In addition to contrast-enhanced mammography (CEM) demonstrating over a 90 percent detection rate for multifocal masses, researchers found that no significant difference between histological measurements and CEM, according to study findings presented at the European Congress of Radiology.
Study: Mammography AI Leads to 29 Percent Increase in Breast Cancer Detection
February 5th 2025Use of the mammography AI software had a nearly equivalent false positive rate as unassisted radiologist interpretation and resulted in a 44 percent reduction in screen reading workload, according to findings from a randomized controlled trial involving over 105,000 women.
